Sung K*, Kurowski A*, Lansiquot C, Wan KK, Patnaik S, Walsh MJ, Lazarus MB. Selective Inhibitors of Autophagy Reveal New Link between the Cell Cycle and Autophagy and Lead to Discovery of Novel Synergistic Drug Combinations. ACS Chem Biol. 2022 Dec 16;17(12):3290-3297. doi: 10.1021/acschembio.2c00710. Epub 2022 Dec 5. PMID: 36469692.

Leandro J, Khamrui S, Suebsuwong C, Chen PJ, Secor C, Dodatko T, Yu C, Sanchez R, DeVita RJ, Houten SM#, Lazarus MB#. Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1. Open Biol. 2022 Sep;12(9):220179. doi: 10.1098/rsob.220179. Epub 2022 Sep 21. PMID: 36128717; PMCID: PMC9490328.

Ingle S, Chhabra S, Chen J, Lazarus MB, Luo X, Bechhofer DH. Discovery and initial characterization of YloC, a novel endoribonuclease in Bacillus subtilis. RNA. 2022 Feb;28(2):227-238. doi: 10.1261/rna.078962.121. Epub 2021 Nov 23. PMID: 34815358; PMCID: PMC8906540.

Baidin V, Owens TW, Lazarus MB, Kahne D. Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase. J Am Chem Soc. 2021 Jan 20;143(2):623-627. doi: 10.1021/jacs.0c11113. Epub 2021 Jan 7. PMID: 33411531; PMCID: PMC7853427.

Leandro J, Khamrui S, Wang H, Suebsuwong C, Nemeria NS, Huynh K, Moustakim M, Secor C, Wang M, Dodatko T, Stauffer B, Wilson CG, Yu C, Arkin MR, Jordan F, Sanchez R, DeVita RJ, Lazarus MB#, Houten SM#. Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex. ACS Chem Biol. 2020 Aug 21;15(8):2041-2047. doi: 10.1021/acschembio.0c00114. Epub 2020 Jul 9. PMID: 32633484; PMCID: PMC7890914.

Khamrui S, Ung PMU, Secor C, Schlessinger A, Lazarus MB. High-Resolution Structure and Inhibition of the Schizophrenia-Linked Pseudokinase ULK4. J Am Chem Soc. 2019 Dec 17. doi: 10.1021/jacs.9b10458

Martin SES, Tan ZW, Itkonen HM, Duveau DY, Paulo JA, Janetzko J, Boutz PL, Törk L, Moss FA, Thomas CJ, Gygi SP, Lazarus MB#, Walker S#. Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors. J Am Chem Soc. 2018 Oct 4. doi: 10.1021/jacs.8b07328.

Lazarus MB, Levin RS, Shokat KM. Discovery of new substrates of the elongation factor-2 kinase suggests a broader role in the cellular nutrient response. Cellular Signaling. 2016. 2016 Oct 17;29:78-83.

Lazarus MB, Shokat KM. Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1. Bioorg Med Chem. 2015 Sep 1;23(17):5483-8.

Ortiz-Meoz RF, Jiang J, Lazarus MB, Orman M, Janetzko J, Fan C, Duveau DY, Tan ZW, Thomas CJ, Walker S. A small molecule that inhibits OGT activity in cells. ACS Chem Biol. 2015 Jun 19;10(6):1392-7.

Lazarus MB#*, Novotny CJ*, Shokat KM#. Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors. ACS Chem Biol. 2015 Jan 16;10(1):257-61.

Sherman DJ, Lazarus MB, Murphy L, Liu C, Walker S, Ruiz N, Kahne D. Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4982-7.

Lazarus MB*, Jiang J*, Kapuria V, Bhuiyan T, Janetzko J, Zandberg WF, Vocadlo DJ, Herr W, Walker S. HCF-1 is cleaved in the active site of O-GlcNAc transferase. Science. 2013 Dec 6;342(6163):1235-9.

Lazarus MB*, Jiang J*, Gloster TM, Zandberg WF, Whitworth GE, Vocadlo DJ, Walker S. Structural snapshots of the reaction coordinate for O-GlcNAc transferase. Nat Chem Biol. 2012 Dec;8(12):966-8.

Jiang J*, Lazarus MB*, Pasquina L, Sliz P, Walker S. A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase. Nat Chem Biol. 2011 Nov 13;8(1):72-7.

Lazarus MB*, Nam Y*, Jiang J, Sliz P, Walker S. Structure of human O-GlcNAc transferase and its complex with a peptide substrate. Nature. 2011 Jan 27;469(7331):564-7.

Boehmerle W, Splittgerber U, Lazarus MB, McKenzie KM, Johnston DG, Austin DJ, Ehrlich BE. Paclitaxel induces calcium oscillations via an inositol 1,4,5-trisphosphate receptor and neuronal calcium sensor 1-dependent mechanism. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18356-61.

Tiyanont K, Doan T, Lazarus MB, Fang X, Rudner DZ, Walker S. Imaging peptidoglycan biosynthesis in Bacillus subtilis with fluorescent antibiotics. Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):11033-8.

#co-corresponding *co-first